Xavier lab reveals how the body fights Covid-19
CMIT Co-Director Ramnik Xavier is one of many CMIT investigators leveraging their expertise and resources to study SARS-CoV-2, the virus that causes Covid-19. Pairing their expertise in immunology with that of computational and structural biologists, members of the Xavier lab reveal the reason why immune responses to Covid-19 vary so widely between individuals. By characterizing […]
Turning microbiome research into a force for health
A diverse group of researchers is working to turn new discoveries about the trillions of microbes in the body into treatments for a range of diseases.
Gut Microbiota Composition and Functional Changes in Inflammatory Bowel Disease and Irritable Bowel Syndrome
Authors unveil a large-scale metagenomic microbiome analysis from patients with both Inflammatory Bowel Disease and Irritable Bowel Syndrome.
Predictive Metabolomic Profiling of Microbial Communities Using Amplicon or Metagenomic Sequences
Researchers create a novel computer model that predicts the metabolic activity of new microbial communities using widely available metagenomic sequencing.
Akkermansia Muciniphila Induces Intestinal Adaptive Immune Responses during Homeostasis
A common intestinal commensal bacteria induces T cell-dependent immunoglobulin production during periods of homeostasis, uncovering a novel pathway through which the microbiome may contribute to immune dysregulation and Inflammatory Bowel Disease.
Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis
In a recent study, researchers use single cell sequencing of intestinal tissue biopsies from diseased and healthy patients to create a cell atlas that lends novel insight into the cellular pathways that link implicated genes to UC pathophysiology.
Multi-omics of the Gut Microbial Ecosystem in Inflammatory Bowel Diseases
In a recently published paper in Nature, Lloyd-Price (et.al) provide a comprehensive analysis of the longitudinal variation in the gut microbiome of patients with IBD.
Ruminococcus gnavus, a Member of the Human Gut Microbiome Associated with Crohn’s Disease, Produces an Inflammatory Polysaccharide
By Katie E. Golden The microbial communities that live peacefully in our gut play a critical role in healthy metabolism and immunity. Evolving research on the microbiome has linked chronic disease, like Inflammatory Bowel Disease (IBD), to significant and characteristic disruptions in both the types and relative abundance of bacterial species that colonize the intestine. […]
New interdisciplinary center at MIT to focus on the microbiome and human health
Partnership with MGH, other institutions to foster regional ecosystem for rapidly evolving field.