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Going for the Gut
Working to preserve human microbiome diversity
Multi-omics of the Gut Microbial Ecosystem in Inflammatory Bowel Diseases
In a recently published paper in Nature, Lloyd-Price (et.al) provide a comprehensive analysis of the longitudinal variation in the gut microbiome of patients with IBD.
Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A
A new approach was taken by researchers who used flow cytometry and gene sequencing in immunodeficient mouse models to identify commensal IgA targets (JJ Bunker at al., Immunity. 2015 Sep 15;43(3):541-53) .
Clinical Collaboration: Fecal Microbiota Transplant as Treatment of Hepatic Encephalopathy
CMIT is collaborating with Dr. Patricia Pringle and Dr. Raymond Chung from Massachusetts General Hospital (MGH) on a new study that is investigating the potential role of fecal microbiota transplantation (FMT) as a treatment for hepatic encephalopathy.
An Interview with Dr. Jessica R. Allegretti, MD, MPH
Dr. Jessica Allegretti is an inspiring example of a clinician who works passionately to improve the lives of those suffering from Inflammatory Bowel Disease (IBD).
A Library of Human Gut Bacterial Isolates Paired with Longitudinal Multiomics Data Enables Mechanistic Microbiome Research
The Broad Institute and OpenBiome Microbiome Library (BIO-ML) now supplies a comprehensive collection of nearly 8,000 intestinal bacterial isolates, paired with nearly 4,000 genome sequences, to serve as an open access investigational resource.
Discovery and Inhibition of an Interspecies Gut Bacterial Pathway for Levodopa Metabolism
One of the promising areas of emerging microbiome research is the impact of our intestinal flora on drug pharmacokinetics.
Leave “Parachute Science” Behind When Jumping Into Global Microbiome Research
The practice of “dropping in” on another country to take whatever is needed to further research, termed “parachute science,” can apply to any scientific field.
First CMIT-HST Clinical Study Award: Scope and Guidelines
The CMIT-HST Clinical Study Award is designed to challenge teams of M.D. and Ph.D. students in the HST program to test their own ideas about the human microbiome in a research study.
Investigating Fecal Microbiota Transplantation as a Treatment for Irritable Bowel Syndrome
Irritable Bowel Syndrome (IBS) is a chronic gastrointestinal disorder that can be associated with daily, debilitating symptoms for patients. Studies suggest that it affects 7-16% of the United States population and 10-15% of the worldwide population, which is predominantly younger people and women.