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How industrialized life remodels the microbiome
A new study from an MIT-led team has revealed that these bacterial populations can remake themselves within the lifetime of their host, by passing genes back and forth.
Turning microbiome research into a force for health
A diverse group of researchers is working to turn new discoveries about the trillions of microbes in the body into treatments for a range of diseases.
Spotlight on Dr. Majdi Osman, MD MPH
An interview with Dr.Majdi Osman, the clinical director of OpenBiome. We talk to Osman about what it’s like to manage the world’s largest stool bank, his ongoing pursuit to try and help children who suffer from malnourishment, and even his extracurricular activity: writing a children’s book!
Development of a Covalent Inhibitor of Gut Bacterial Bile Salt Hydrolases
To better understand the pathologic impact of intestinal bile acids on host health, CMIT faculty designed a non-toxic inhibitor that reduces secondary bile acid production in the intestine to better understand the impact of these metabolites.
Gut Microbiota Composition and Functional Changes in Inflammatory Bowel Disease and Irritable Bowel Syndrome
Authors unveil a large-scale metagenomic microbiome analysis from patients with both Inflammatory Bowel Disease and Irritable Bowel Syndrome.
Predictive Metabolomic Profiling of Microbial Communities Using Amplicon or Metagenomic Sequences
Researchers create a novel computer model that predicts the metabolic activity of new microbial communities using widely available metagenomic sequencing.
Functional Heterogeneity in the Fermentation Capabilities of the Healthy Human Gut Microbiota
A new study by Gurry and fellow CMIT colleagues explores the relationship between fiber intake and microbial Short Chain Fatty Acid production
Manuscript Highlight: Synthetic Gene Circuits Enable Systems-Level Biosensor Trigger Discovery at the Host-Microbe Interface
Engineered microbes with condition-responsive circuits can be used to record physiological and environmental conditions as they pass through the gut.
Manuscript Highlight: Akkermansia Muciniphila Induces Intestinal Adaptive Immune Responses during Homeostasis
A common intestinal commensal bacteria induces T cell-dependent immunoglobulin production during periods of homeostasis, uncovering a novel pathway through which the microbiome may contribute to immune dysregulation and Inflammatory Bowel Disease.
Manuscript Highlight: Pathway Paradigms Revealed from the Genetics of Inflammatory Bowel Disease
In a recently published paper in Nature, CMIT faculty provide a comprehensive review of the scientific advances that have brought us to our current understanding of Inflammatory Bowel Disease (IBD) pathophysiology.