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Manuscript Highlight: Pathway Paradigms Revealed from the Genetics of Inflammatory Bowel Disease
In a recently published paper in Nature, CMIT faculty provide a comprehensive review of the scientific advances that have brought us to our current understanding of Inflammatory Bowel Disease (IBD) pathophysiology.
Growth Effects of N-acylethanolamines on Gut Bacteria Reflect Altered Bacterial Abundances in Inflammatory Bowel Disease
Researchers identify a specific lipid metabolite that is abnormally abundant in IBD patients. Their subsequent investigations reveal how this metabolite stimulates the growth of species that are well established to be overrepresented in IBD patients.
Summary: Cryo-electron Microscopy Structures of Human Oligosaccharyltransferase Complexes OST-A and OST-B
Investigators expand on prior CMIT research to define the chemical structure of two important glycosylation enzymes. By combining advanced cryo-electron microscopy with traditional western blot analysis, scientists identify the subtle structural differences in two related human oligosaccharyltransferase complexes that accounts for their unique cellular functions.

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