A common intestinal commensal bacteria induces T cell-dependent immunoglobulin production during periods of homeostasis, uncovering a novel pathway through which the microbiome may contribute to immune dysregulation and Inflammatory Bowel Disease.
In a recent study, researchers use single cell sequencing of intestinal tissue biopsies from diseased and healthy patients to create a cell atlas that lends novel insight into the cellular pathways that link implicated genes to UC pathophysiology.
By Katie E. Golden The microbial communities that live peacefully in our gut play a critical role in healthy metabolism and immunity. Evolving research on the microbiome has linked chronic disease, like Inflammatory Bowel Disease (IBD), to significant and characteristic disruptions in both the types and relative abundance of bacterial species that colonize the intestine. […]