Searching for bacteria that protect against IBD
CMIT researchers are pinpointing bacterial species that trigger the development of special immune cells which may be protective against ulcerative colitis and other inflammatory disorders.
Gut Microbiota Composition and Functional Changes in Inflammatory Bowel Disease and Irritable Bowel Syndrome
Authors unveil a large-scale metagenomic microbiome analysis from patients with both Inflammatory Bowel Disease and Irritable Bowel Syndrome.
Functional Heterogeneity in the Fermentation Capabilities of the Healthy Human Gut Microbiota
A new study by Gurry and fellow CMIT colleagues explores the relationship between fiber intake and microbial Short Chain Fatty Acid production
Synthetic Gene Circuits Enable Systems-Level Biosensor Trigger Discovery at the Host-Microbe Interface
Engineered microbes with condition-responsive circuits can be used to record physiological and environmental conditions as they pass through the gut.
Akkermansia Muciniphila Induces Intestinal Adaptive Immune Responses during Homeostasis
A common intestinal commensal bacteria induces T cell-dependent immunoglobulin production during periods of homeostasis, uncovering a novel pathway through which the microbiome may contribute to immune dysregulation and Inflammatory Bowel Disease.
Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis
In a recent study, researchers use single cell sequencing of intestinal tissue biopsies from diseased and healthy patients to create a cell atlas that lends novel insight into the cellular pathways that link implicated genes to UC pathophysiology.
Multi-omics of the Gut Microbial Ecosystem in Inflammatory Bowel Diseases
In a recently published paper in Nature, Lloyd-Price (et.al) provide a comprehensive analysis of the longitudinal variation in the gut microbiome of patients with IBD.
An Interview with Dr. Jessica R. Allegretti, MD, MPH
Dr. Jessica Allegretti is an inspiring example of a clinician who works passionately to improve the lives of those suffering from Inflammatory Bowel Disease (IBD).