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Synthetic Gene Circuits Enable Systems-Level Biosensor Trigger Discovery at the Host-Microbe Interface
Engineered microbes with condition-responsive circuits can be used to record physiological and environmental conditions as they pass through the gut.
Akkermansia Muciniphila Induces Intestinal Adaptive Immune Responses during Homeostasis
A common intestinal commensal bacteria induces T cell-dependent immunoglobulin production during periods of homeostasis, uncovering a novel pathway through which the microbiome may contribute to immune dysregulation and Inflammatory Bowel Disease.
Pathway Paradigms Revealed from the Genetics of Inflammatory Bowel Disease
In a recently published paper in Nature, CMIT faculty provide a comprehensive review of the scientific advances that have brought us to our current understanding of Inflammatory Bowel Disease (IBD) pathophysiology.
Growth Effects of N-acylethanolamines on Gut Bacteria Reflect Altered Bacterial Abundances in Inflammatory Bowel Disease
Researchers identify a specific lipid metabolite that is abnormally abundant in IBD patients. Their subsequent investigations reveal how this metabolite stimulates the growth of species that are well established to be overrepresented in IBD patients.
Cryo-electron Microscopy Structures of Human Oligosaccharyltransferase Complexes OST-A and OST-B
Investigators expand on prior CMIT research to define the chemical structure of two important glycosylation enzymes. By combining advanced cryo-electron microscopy with traditional western blot analysis, scientists identify the subtle structural differences in two related human oligosaccharyltransferase complexes that accounts for their unique cellular functions.
Engineering Phage Host-Range and Suppressing Bacterial Resistance through Phage Tail Fiber Mutagenesis
Performing targeted mutagenesis of specific phage regions that are critical for bacterial recognition, creating diversity at binding regions that slows evolution of bacterial resistance mechanisms.
Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis
In a recent study, researchers use single cell sequencing of intestinal tissue biopsies from diseased and healthy patients to create a cell atlas that lends novel insight into the cellular pathways that link implicated genes to UC pathophysiology.
Spotlight on Dr. Duane Wesemann, MD, PhD
Interview with Dr. Duane Wesemann, an Assistant Professor at Harvard Medical School, and a Principal investigator in the Division of Rheumatology, Immunology and Allergy at the Brigham and Women’s Hospital.
Framework for Rational Donor Selection in Fecal Microbiota Transplant Clinical Trials
Fecal Microbiota Transplant (FMT) is gaining traction as a potentially effect treatment of the increasing number of diseases that have been linked to microbiome dysbiosis.