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Natural Polyreactive IgA Antibodies Coat the Intestinal Microbiota
Summary by Dr. Katie Golden, MD Immunoglobulin A (IgA), an antibody produced by plasma cells that plays a pivotal role in adaptive immunity, is the most abundant mammalian antibody. It is often found at barrier surfaces, such as the intestinal mucosa, where it serves as a first line of defense against enteric pathogens. IgA responses […]
Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A
Summary by Katie Golden Immunoglobulin A (IgA) is a prominent, widely distributed antibody that plays a critical role in host defense and immune function. Over 80% of all human plasma cells produce IgA and are found in the intestinal mucosa. Research has historically focused on IgA’s role in immunity against pathogenic organisms, but less is […]