Mechanisms of Pediatric Inflammatory Bowel Disease

Inflammatory bowel disease (IBD), including Crohn disease and ulcerative colitis, is characterized by chronic intestinal inflammation due to a complex interaction of genetic determinants, disruption of mucosal barriers, aberrant inflammatory signals, loss of tolerance, and environmental triggers. Importantly, the incidence of pediatric IBD is rising, particularly in children younger than 10 years. In this review, […]

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The Microbiome and Inflammatory Bowel Disease: Driver or Passenger?

An Interview with Dr. Ashwin Ananthakrishnan Dr. Ashwin Ananthakrishnan is a gastroenterologist at Massachusetts General Hospital and performs innovative research focusing on the epidemiology and outcomes of inflammatory bowel diseases. Here he discusses with the Center of Microbiome Informatics and Therapeutics the relationship between inflammatory bowel disease and the microbiome.   What is Inflammatory Bowel […]

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Top Posts of IBD Awareness Week 2015


The first week in December is internationally known as Inflammatory Bowel Disease (IBD) Awareness Week. Designed to spread knowledge and awareness of the often “invisible” disease of IBD, thousands of people shared stories and information using the hashtags #IBDAware and #IBDAwarenessWeek. Below are some of the Center for Microbiome Informatics and Therapeutics’ favorite posts from […]

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Are all stools created equal? Donor Effects in Treating Ulcerative Colitis with FMT

This post was written by Thomas Gurry, a Postdoctoral Associate in the Center for Microbiome Informatics and Therapeutics. Fecal Microbiota Transplantation (FMT) has proven itself to be a highly effective intervention for patients suffering from recurrent Clostridium difficile (C. diff) infection. This success has prompted an explosion of interest in FMT as a potential clinical strategy […]

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