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The Colitis Risk Gene C1orf106 (ROCS) Regulates Epithelial Adherens Junction Stability
Summary by Katie Golden With the recent technical advances in genetic sequencing, a number of genes and polymorphisms have been identified that confer increased risk for Inflammatory Bowel Disease (IBD). Scientific research has not yet elucidated, however, the mechanisms through which these genes promote the pathophysiology of IBD. In this paper, investigators studied the specific […]
Dynamics of Metatranscription in the Inflammatory Bowel Disease Gut Microbiome
Summary by Katie Golden Scientists have identified several genetic mutations implicated in Inflammatory Bowel Disease (IBD), and recent research has focused on defining those environmental factors that affect expression of these genes. Over the past decade, investigators have to come to realize that the gut microbiome plays a central role in IBD development and progression. […]
Natural Polyreactive IgA Antibodies Coat the Intestinal Microbiota
Summary by Dr. Katie Golden, MD Immunoglobulin A (IgA), an antibody produced by plasma cells that plays a pivotal role in adaptive immunity, is the most abundant mammalian antibody. It is often found at barrier surfaces, such as the intestinal mucosa, where it serves as a first line of defense against enteric pathogens. IgA responses […]
Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A
Summary by Katie Golden Immunoglobulin A (IgA) is a prominent, widely distributed antibody that plays a critical role in host defense and immune function. Over 80% of all human plasma cells produce IgA and are found in the intestinal mucosa. Research has historically focused on IgA’s role in immunity against pathogenic organisms, but less is […]