Designing fecal microbiota transplant trials that account for differences in donor stool efficacy

by Scott Olesen Microbes appear to be involved in a complicated interaction with their human hosts, protecting us from some diseases and possibly helping to cause others. Gut microbiota are suspected to be involved in inflammatory bowel disease, a condition where the human body’s immune system attacks its own digestive system. Inflammatory bowel disease, or […]

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Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability

Yassour M et al. (Xavier Lab) Abstract The gut microbial community is dynamic during the first 3 years of life, before stabilizing to an adult-like state. However, little is known about the impact of environmental factors on the developing human gut microbiome. We report a longitudinal study of the gut microbiome based on DNA sequence […]

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The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes

Colonization of the fetal and infant gut microbiome results in dynamic changes in diversity, which can impact disease susceptibility. To examine the relationship between human gut microbiome dynamics throughout infancy and type 1 diabetes (T1D), we examined a cohort of 33 infants genetically predisposed to T1D. Modeling trajectories of microbial abundances through infancy revealed a […]

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