Clostridium difficile – The Center for Microbiome Informatics and Therapeutics

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Designing fecal microbiota transplant trials that account for differences in donor stool efficacy.

Olesen, S.W., et al. Stat Methods Med Res. 2017 Jan 1:962280216688502 Fecal microbiota transplantation is a highly effective intervention for patients suffering from recurrent Clostridium difficile, a common hospital-acquired infection. Fecal microbiota transplantation’s success as a therapy for C. difficile has inspired interest in performing clinical trials that experiment with fecal microbiota transplantation as a therapy for […]

Profiling Living Bacteria Informs Preparation of Fecal Microbiota Transplantations.

Chu, N.D., et al., PLoS One. 2017 Jan 26;12(1):e0170922. doi: 10.1371/journal.pone.0170922 Fecal microbiota transplantation is a compelling treatment for recurrent Clostridium difficile infections, with potential applications against other diseases associated with changes in gut microbiota. But variability in fecal bacterial communities-believed to be the therapeutic agent-can complicate or undermine treatment efficacy. To understand the effects of transplant […]

Designing fecal microbiota transplant trials that account for differences in donor stool efficacy

by Scott Olesen Microbes appear to be involved in a complicated interaction with their human hosts, protecting us from some diseases and possibly helping to cause others. Gut microbiota are suspected to be involved in inflammatory bowel disease, a condition where the human body’s immune system attacks its own digestive system. Inflammatory bowel disease, or […]

The Microbiome and Inflammatory Bowel Disease: Driver or Passenger?

An Interview with Dr. Ashwin Ananthakrishnan Dr. Ashwin Ananthakrishnan is a gastroenterologist at Massachusetts General Hospital and performs innovative research focusing on the epidemiology and outcomes of inflammatory bowel diseases. Here he discusses with the Center of Microbiome Informatics and Therapeutics the relationship between inflammatory bowel disease and the microbiome. What is Inflammatory Bowel […]

How Should the FDA Regulate Fecal Transplantation Safely and Effectively?

This post written by Rachel Sachs originally appeared in the Bill of Health blog. A draft version of the paper referred to in this blog post, co-authored by Sachs and Edelstein, is now available here. [An early December] issue of the New Yorker featured a terrific article about fecal microbiota transplantation, or FMT. Much of […]