[Center Publication] C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions. V Mohanan et al., http://science.sciencemag.org/content/early/2018/01/31/science.aan0814.full

Abstract Polymorphisms in C1orf106 are associated with increased risk of inflammatory bowel disease (IBD). However, the function of C1orf106 and the consequences of disease-associated polymorphisms are unknown. Here we demonstrate that C1orf106 regulates adherens junction stability by regulating the degradation of cytohesin-1, a guanine nucleotide exchange factor that controls activation of ARF6. By limiting cytohesin-1-dependent ARF6 activation, […]

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[Center Publication] Dynamics of metatranscription in the inflammatory bowel disease gut microbiome. M. Schirmer et al., Nat Microbiol. 2018 Jan 8

Abstract Inflammatory bowel disease (IBD) is a group of chronic diseases of the digestive tract that affects millions of people worldwide. Genetic, environmental and microbial factors have been implicated in the onset and exacerbation of IBD. However, the mechanisms associating gut microbial dysbioses and aberrant immune responses remain largely unknown. The integrative Human Microbiome Project seeks to close these gaps by examining […]

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[Center Publication] Meta-analysis of gut microbiome studies identifies disease-specific and shared responses. C Duvallet, et al., Nat Commun. 2017 Dec 5;8(1):1784

Abstract Hundreds of clinical studies have demonstrated associations between the human microbiome and disease, yet fundamental questions remain on how we can generalize this knowledge. Results from individual studies can be inconsistent, and comparing published data is further complicated by a lack of standard processing and analysis methods. Here we introduce the MicrobiomeHD database, which […]

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A single-cell survey of the small intestinal epithelium

Haber AL, et al., Nature. 2017 Nov 16;551(7680):333-339. doi: 10.1038/nature24489 Intestinal epithelial cells absorb nutrients, respond to microbes, function as a barrier and help to coordinate immune responses. Here we report profiling of 53,193 individual epithelial cells from the small intestine and organoids of mice, which enabled the identification and characterization of previously unknown subtypes of intestinal […]

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Salt-responsive gut commensal modulates TH17 axis and disease

Wilck N. et al.,  Nature. 2017 Nov 15. doi: 10.1038/nature24628.  A Western lifestyle with high salt consumption can lead to hypertension and cardiovascular disease. High salt may additionally drive autoimmunity by inducing T helper 17 (TH17) cells, which can also contribute to hypertension. Induction of TH17 cells depends on gut microbiota; however, the effect of salt […]

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