Research Overview by Dr. Katie Golden, MD: C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions (V. Mohanan et al., https://doi.org/10.1126/science.aan0814)

With the recent technical advances in genetic sequencing, a number of genes and polymorphisms have been identified that confer increased risk for Inflammatory Bowel Disease (IBD). Scientific research has not yet elucidated, however, the mechanisms through which these genes promote the pathophysiology of IBD. In this paper, investigators studied the specific gene C1orf106, and describe […]

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Research Overview by Dr. Katie Golden MD: Dynamics of Metatranscription in the Inflammatory Bowel Disease Gut Microbiome (Schirmer M., et al., Nat Microbiol. 2018 Jan 8)

Scientists have identified several genetic mutations implicated in Inflammatory Bowel Disease (IBD), and recent research has focused on defining those environmental factors that affect expression of these genes. Over the past decade, investigators have to come to realize that the gut microbiome plays a central role in IBD development and progression. The relationship between variations […]

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Research Overview by Dr. Katie Golden, MD: Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A (JJ Bunker et al., Immunity. 2015 Sep 15;43(3):541-53)

Immunoglobulin A (IgA) is a prominent, widely distributed antibody that plays a critical role in host defense and immune function. Over 80% of all human plasma cells produce IgA and are found in the intestinal mucosa. Research has historically focused on IgA’s role in immunity against pathogenic organisms, but less is known about its equally […]

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Research Overview by Dr. Katie Golden, MD: Natural Polyreactive IgA Antibodies Coat the Intestinal Microbiota

Immunoglobulin A (IgA), an antibody produced by plasma cells that plays a pivotal role in adaptive immunity, is the most abundant mammalian antibody. It is often found at barrier surfaces, such as the intestinal mucosa, where it serves as a first line of defense against enteric pathogens. IgA responses are continually active under normal homeostatic […]

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Research Overview by Dr. Katie Golden, MD: Quantitative Microbiome Profiling Links Gut Community Variation to Microbial Load

As our understanding of microbiome-associated disease evolves, the scientific community must be rigorous in questioning their investigative techniques in order to best understand and characterize the connection between gut microbiota and disease development.  Our current understanding of the microbiome often comes from sequencing-based analysis of fecal samples, which characterizes flora based on relative abundance in […]

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