A Microbiome Foundation for the Study of Crohn’s Disease.

D. Gevers et al., Cell Host Microbe. 2017 Mar 8;21(3):301-304. doi: 10.1016/j.chom.2017.02.012 Our 2014 study published in Cell Host & Microbe, “The Treatment-Naive Microbiome in New-Onset Crohn’s Disease,” was designed to improve our understanding of the microbiome’s role in Crohn’s disease by studying a unique, well-suited cohort and sample set. This commentary provides a hindsight perspective of […]

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Unraveling the processes shaping mammalian gut microbiomes over evolutionary time.

Groussin, M. et al., Nat Commun. 2017 Feb 23;8:14319. doi: 10.1038/ncomms14319 Whether mammal-microbiome interactions are persistent and specific over evolutionary time is controversial. Here we show that host phylogeny and major dietary shifts have affected the distribution of different gut bacterial lineages and did so on vastly different bacterial phylogenetic resolutions. Diet mostly influences the acquisition of […]

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Two dynamic regimes in the human gut microbiome.

Gibbons, S.M.., et al., PLoS Comput Biol. 2017 Feb 21;13(2):e1005364. doi: 10.1371/journal.pcbi.1005364 The gut microbiome is a dynamic system that changes with host development, health, behavior, diet, and microbe-microbe interactions. Prior work on gut microbial time series has largely focused on autoregressive models (e.g. Lotka-Volterra). However, we show that most of the variance in microbial time series […]

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Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity

Schirmer M, et al (Xavier Lab) Cell. 2016 Nov 3;167(4):1125-1136.e8. doi: 10.1016/j.cell.2016.10.020. Gut microbial dysbioses are linked to aberrant immune responses, which are often accompanied by abnormal production of inflammatory cytokines. As part of the Human Functional Genomics Project (HFGP), we investigate how differences in composition and function of gut microbial communities may contribute to […]

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