Unraveling the processes shaping mammalian gut microbiomes over evolutionary time.

Groussin, M. et al., Nat Commun. 2017 Feb 23;8:14319. doi: 10.1038/ncomms14319 Whether mammal-microbiome interactions are persistent and specific over evolutionary time is controversial. Here we show that host phylogeny and major dietary shifts have affected the distribution of different gut bacterial lineages and did so on vastly different bacterial phylogenetic resolutions. Diet mostly influences the acquisition of […]

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Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity

Schirmer M, et al (Xavier Lab) Cell. 2016 Nov 3;167(4):1125-1136.e8. doi: 10.1016/j.cell.2016.10.020. Gut microbial dysbioses are linked to aberrant immune responses, which are often accompanied by abnormal production of inflammatory cytokines. As part of the Human Functional Genomics Project (HFGP), we investigate how differences in composition and function of gut microbial communities may contribute to […]

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Finding a niche

This post was written by Sean Gibbons, a Post-Doctoral Associate with Eric Alm at MIT The field of invasion ecology attempts to understand how and why certain species are able to invade or colonize territory outside of their native ranges. Human shipping and transportation activities have greatly increased the dispersal of animal and plant species across […]

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Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity

Deep sequencing of the gut microbiomes of 1135 participants from a Dutch population-based cohort shows relations between the microbiome and 126 exogenous and intrinsic host factors, including 31 intrinsic factors, 12 diseases, 19 drug groups, 4 smoking categories, and 60 dietary factors. These factors collectively explain 18.7% of the variation seen in the interindividual distance […]

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