Gut Microbiome Function Predicts Response to Anti-integrin Biologic Therapy in Inflammatory Bowel Diseases.

Ananthakrishnan AN et al., Cell Host Microbe. 2017 May 10;21(5):603-610.e3. doi: 10.1016/j.chom.2017.04.010. The gut microbiome plays a central role in inflammatory bowel diseases (IBDs) pathogenesis and propagation. To determine whether the gut microbiome may predict responses to IBD therapy, we conducted a prospective study with Crohn’s disease (CD) or ulcerative colitis (UC) patients initiating anti-integrin therapy (vedolizumab). Disease […]

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Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity

Schirmer M, et al (Xavier Lab) Cell. 2016 Nov 3;167(4):1125-1136.e8. doi: 10.1016/j.cell.2016.10.020. Gut microbial dysbioses are linked to aberrant immune responses, which are often accompanied by abnormal production of inflammatory cytokines. As part of the Human Functional Genomics Project (HFGP), we investigate how differences in composition and function of gut microbial communities may contribute to […]

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Finding a niche

This post was written by Sean Gibbons, a Post-Doctoral Associate with Eric Alm at MIT The field of invasion ecology attempts to understand how and why certain species are able to invade or colonize territory outside of their native ranges. Human shipping and transportation activities have greatly increased the dispersal of animal and plant species across […]

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Tracking Strains in the Microbiome: Insights from Metagenomics and Models

Transmission usually refers to the movement of pathogenic organisms. Yet, commensal microbes that inhabit the human body also move between individuals and environments. Surprisingly little is known about the transmission of these endogenous microbes, despite increasing realizations of their importance for human health. The health impacts arising from the transmission of commensal bacteria range widely, […]

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