Prediction of complicated disease course for children newly diagnosed with Crohn’s disease: a multicentre inception cohort study.

Kugathasan S., et al., Lancet. 2017 Apr 29;389(10080):1710-1718. doi: 10.1016/S0140-6736(17)30317-3 Stricturing and penetrating complications account for substantial morbidity and health-care costs in paediatric and adult onset Crohn’s disease. Validated models to predict risk for complications are not available, and the effect of treatment on risk is unknown. METHODS: We did a prospective inception cohort study of paediatric […]

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A Microbiome Foundation for the Study of Crohn’s Disease.

D. Gevers et al., Cell Host Microbe. 2017 Mar 8;21(3):301-304. doi: 10.1016/j.chom.2017.02.012 Our 2014 study published in Cell Host & Microbe, “The Treatment-Naive Microbiome in New-Onset Crohn’s Disease,” was designed to improve our understanding of the microbiome’s role in Crohn’s disease by studying a unique, well-suited cohort and sample set. This commentary provides a hindsight perspective of […]

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