Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.

Johannessen L., et al. Nat Chem Biol. 2017 Oct;13(10):1102-1108. doi: 10.1038/nchembio.2458 Enhancing production of the anti-inflammatory cytokine interleukin-10 (IL-10) is a promising strategy to suppress pathogenic inflammation. To identify new mechanisms regulating IL-10 production, we conducted a phenotypic screen for small molecules that enhance IL-10 secretion from activated dendritic cells. Mechanism-of-action studies using a prioritized hit from […]

Read more

Top