The 27th Annual Workshop of the Center for the Study of Inflammatory Bowel Disease (CSIBD)

and

The Second Annual Symposium of the Center for Microbiome Informatics and Therapeutics

Genetics, Microbes, and Immunity in Inflammatory Bowel Disease

To register, please e-mail lblizard@partners.org

Thursday November 2, 2017

7:30 – 8:00     Registration and Breakfast

8:00 – 8:10     Opening Remarks – Ramnik J. Xavier, M.D. – Director, CSIBD, and

Director, Center for Microbiome Informatics and Therapeutics MIT

Session I: CSIBD Forum

8:10 – 8:30     Reverse Metabolomics and Genetic Tools for Studying Metabolism      

Russell Goodman M.D., Ph.D., Gastrointestinal Unit, Massachusetts General Hospital

8:35 – 8:55     Talk Title Pending

Georg Lauer, M.D., Ph.D., Gastrointestinal Unit, Massachusetts General Hospital

9:00 – 9:20     Long Noncoding RNAs in Fibrosis

Alan Mullen, M.D., Ph.D., Gastrointestinal Unit, Massachusetts General Hospital

9:25 – 9:40     Break

9:45 – 10:05   Defining Neuronal Subclasses in the Enteric Nervous System Using Single Cell Transcriptomics

Aylwin Ng Ph.D., Gastrointestinal Unit, Massachusetts General Hospital

10:10 – 10:30  Targeting CTLA-4 with High-Affinity Single Domain Antibodies

Michael Dougan, M.D., Ph.D., Gastrointestinal Unit, Massachusetts General Hospital

10:35 – 10:55  Broad Microbiome Library

Mathilde Poyet, Ph.D., Postdoctoral Associate, Eric Alm’s laboratory, MIT

Keynote Address

11:00 – 12:00    Strain-tracking reveals the determinants of bacterial engraftment in the human gut following fecal microbiota transplantation

Eric Alm, Ph.D., Director, Center for Microbiome Informatics and Therapeutics MIT

12:00 – 2:00    Lunch Break

Session II: Center for Microbiome Informatics and Therapeutics Research Forum

Chair: Hera Vlamakis, Ph.D., Group Leader / Research Scientist, The Broad Institute

2:00 – 2:20     Talk Title Pending

Eric Franzosa, Ph.D., Research Scientist, Curtis Huttenhower’s laboratory

Harvard T.H. Chan School of Public Health

2:25 – 2:45     Fecal Microbiota Transplantation for the Treatment of Primary Sclerosis Cholangitis 

Jessica Allegretti, M.D., M.P.H., Gastroenterology and Hepatology Division, Brigham and Women’s Hospital

2:50 – 3:10     Unsupervised novel lineage classification using Bayesian nonparametrics

Ashwin Narayan, Research Associate, Bonnie Berger’s laboratory, MIT

3:15 – 3:35     The Global Microbiome Conservancy: Advancing Human Health Through the Exploration of our Global Microbial Heritage

Mathieu Groussin, Ph.D., Postdoctoral Associate, Eric Alm’s laboratory, MIT

3:40 – 3:55     Break

4:00 – 4:20     Broad Next 10

Sean Gibbons, MSc., Ph.D., Postdoctoral Associate, Eric Alm’s laboratory, MIT

4:25 – 4:45     Dynamics of Metatranscription in the Inflammatory Bowel Disease Gut Microbiome

Melanie Schirmer, Ph.D., Postdoctoral Associate, Xavier and Huttenhower laboratories, The Broad Institute of MIT and Harvard

4:50 – 5:15     Adaptation of commensal bacteria within individual healthy people

Tami Lieberman, Ph.D., Postdoctoral Associate, Eric Alm’s laboratory, MIT

Friday November 3, 2017

7:00 – 7:40: Registration and Breakfast

Session I: Computation to Small Molecules

Moderators: Andrew Chan, M.D. and Andrew Luster, M.D., Ph.D

8:00 – 8:25        Integrating dynamic profiles of the microbiome in inflammatory bowel disease

Curtis Huttenhower, Ph.D., Harvard School of Public Health, Boston, MA

8:30–8:55          Metabolic Profiling through Mass Spectrometry

Elizabeth Kujawinski, Ph.D., Woods Hole Oceanographic Institute, Wood Holes, MA

9:00–9:25          Our intestinal microbiota as a source of next-generation probiotics to prevent and to treat inflammatory bowel diseases?

Philippe Langella, Ph.D., Micalis Institute, France

9:30–9:55          Discovering, understanding, and harnessing microbiota-drug interactions

Emily Balskus, Ph.D., Harvard University, Cambridge, MA

10:00–10:15      Break

Session II: Mucus, Phage, and IBD

Moderators: Mark Daly, Ph.D. and Gail Hecht, M.D.

10:20 – 10:45    Probing microbial interactions with the mucus barrier

Katharina Ribbeck, Ph.D., MIT, Cambridge, MA

10:50 – 11:15    New insights on microbiome-based diagnostics, cholesterol metabolism and virus dynamics

Sepideh Pakpour, Ph.D., MIT, Cambridge, MA

11:20 – 11:45    A humanized fecal transplantation mouse model to study the functionality of the gut microbiome

Fabio Cominelli, M.D., Ph.D., Case Western Reserve University, Cleveland, OH

11:50 – 12:15    Modulation of inflammation and intestinal damage in the intestine but host factors

Thaddeus Stappenbeck, M.D., Ph.D., Washington University School of Medicine, St. Louis, MO

Session III: Systems Biology and IBD

Moderators: Hera Vlamakis, Ph.D. and Charles Elson, M.D.

1:20 – 1:45       Molecular details of glycan scavenging by human gut Bacteroidetes

Nicole Koropatkin, Ph.D., University of Michigan, Ann Arbor, MI

1:50 – 2:15      Genomic Profiling of the Inflamed Colon at Single Cell Resolution

Aviv Regev, Ph.D., The Broad Institute, Cambridge, MA

2:20 – 2:45       Bioactive Small Molecules Metabolized By Human Gut Bacteria

Sloan Devlin, Ph.D., Harvard Medical School, Cambridge, MA

2:50 – 3:15       Butyrate: a link between us and our microbiome

Mohit Verma, Ph.D., Purdue University, West Lafayette, IN

3:20 – 3:35        Break

Session IV: Signaling Circuits and Microbiome in Health and Disease

Moderators: Shiv Pillai, Ph.D. and Hans-Christian Reinecker, Ph.D.

3:40 – 4:05      Causes and consequences of microbiome variation

Andrew Goodman, Ph.D., Yale University, New Haven, CT

4:10 – 4:35       Engineering in vivo non-invasive diagnostics via the microbiome

Timothy Lu, M.D., Ph.D., MIT, Cambridge, MA

4:40 – 5:05       Synthetic biology diagnostics for the gut microbiome

Jim Collins, Ph.D., MIT, Cambridge, MA

Location: Simches Research Building at Charles River Plaza, 185 Cambridge Street, 3rd floor
Event is open to the research community at no charge
To register: e-mail lblizard@partners.org
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