Research Overview by Dr. Katie Golden, MD: Ectopic Colonization of Oral Bacteria in the Intestine Drives TH1 Cell Induction and Inflammation

Prior studies have shown a correlation between intestinal colonization of oral bacteria and inflammatory bowel disease. It remains unclear, however, if there is a causal relationship between this aberrant bacterial growth and gut inflammation. In a recent publication in Science by Atarashi et al., researchers isolated a specific strain of bacteria from human saliva, and describe how […]

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Research Overview by Dr. Katie Golden, MD: A single-cell survey of the small intestinal epithelium

The intestinal mucosa is home to the most diverse epithelial tissue in the body, but our current understanding of this cell population is limited. In a new study published by Haber et.al in Nature, researchers apply next generation DNA sequencing, which allows for higher resolution investigation, to this heterogenous group of cells. The result is […]

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Research Overview by Dr. Katie Golden, MD: Salt-responsive gut commensal modulates TH17 axis and disease

High salt intake is a known contributor to the development of hypertension. The mechanisms through which salt induces elevated blood pressures are still under investigation, and the majority of research has focused on the renal and nervous systems as key players. Despite a well established link between dietary salt and hypertension, however, we know surprisingly […]

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From Harvard Magazine, Gut Health May Begin in the Mouth

By LYDIALYLE GIBSON in Harvard Magazine 10.20.17 CHRONIC GASTROINTESTINAL PROBLEMS may begin with what is in a patient’s mouth. In a study published Thursday in Science, an international team of researchers—including one from Harvard—reported on strains of oral bacteria that, when swallowed in the 1.5 liters of saliva that people ingest every day, can lodge in the gut […]

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Finding a niche

This post was written by Sean Gibbons, a Post-Doctoral Associate with Eric Alm at MIT The field of invasion ecology attempts to understand how and why certain species are able to invade or colonize territory outside of their native ranges. Human shipping and transportation activities have greatly increased the dispersal of animal and plant species across […]

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