Research Overview by Dr. Katie Golden, MD: Natural Polyreactive IgA Antibodies Coat the Intestinal Microbiota

Immunoglobulin A (IgA), an antibody produced by plasma cells that plays a pivotal role in adaptive immunity, is the most abundant mammalian antibody. It is often found at barrier surfaces, such as the intestinal mucosa, where it serves as a first line of defense against enteric pathogens. IgA responses are continually active under normal homeostatic […]

Read more

Research Overview by Dr. Katie Golden, MD: Quantitative Microbiome Profiling Links Gut Community Variation to Microbial Load

As our understanding of microbiome-associated disease evolves, the scientific community must be rigorous in questioning their investigative techniques in order to best understand and characterize the connection between gut microbiota and disease development.  Our current understanding of the microbiome often comes from sequencing-based analysis of fecal samples, which characterizes flora based on relative abundance in […]

Read more

Research Overview by Dr. Katie Golden, MD: Ectopic Colonization of Oral Bacteria in the Intestine Drives TH1 Cell Induction and Inflammation

Prior studies have shown a correlation between intestinal colonization of oral bacteria and inflammatory bowel disease. It remains unclear, however, if there is a causal relationship between this aberrant bacterial growth and gut inflammation. In a recent publication in Science by Atarashi et al., researchers isolated a specific strain of bacteria from human saliva, and describe how […]

Read more

Research Overview by Dr. Katie Golden, MD: A single-cell survey of the small intestinal epithelium

The intestinal mucosa is home to the most diverse epithelial tissue in the body, but our current understanding of this cell population is limited. In a new study published by Haber et.al in Nature, researchers apply next generation DNA sequencing, which allows for higher resolution investigation, to this heterogenous group of cells. The result is […]

Read more

Research Overview by Dr. Katie Golden, MD: Salt-responsive gut commensal modulates TH17 axis and disease

High salt intake is a known contributor to the development of hypertension. The mechanisms through which salt induces elevated blood pressures are still under investigation, and the majority of research has focused on the renal and nervous systems as key players. Despite a well established link between dietary salt and hypertension, however, we know surprisingly […]

Read more

Top